Organization and Function of Cortical Circuits

We are studying the organization and function of neural circuits in the visual cortex to better understand how specific neural components contribute to the computations that give rise to visual perception and to elucidate the basic neural mechanisms that underlie cortical function. We employ anatomical and physiological methods both in vivo and in vitro to reveal neuronal circuitry and to identify the emergent functional properties of the component neurons.

Present studies focus on: identifying the roles of specific cell types in cortical function by mapping their connections, and monitoring and manipulating their activity using genetic and viral tools; understanding the contributions of cortical and subcortical structures and cell types to functional interactions between visual cortical areas; understanding the neural mechanisms that underlie changes in behavioral performance with attention and that regulate shifts in attention.

We are also actively developing and utilizing molecular and genetic methods to facilitate the elucidation and manipulation of neural circuits. These methods include: development of promoters that drive gene expression specifically in cell types of interest; selective trans-synaptic viral labeling of neural circuits; viral delivery of genetic material to allow manipulation of circuits in species where typical transgenic technologies are presently impractical.

Personnel

Ed Callaway
Professor and principal investigator
858-453-4100 x1158
callaway@salk.edu

Amanda Casale
Postdoctoral fellow
858-453-4100 x1073
acasale@salk.edu

Dhru Chatterjee
Research assistant
858-453-4100 x1326
dchatterjee@salk.edu

Hannah Collins
Lab assistant
858-453-4100 x1073
hcollins@salk.edu

Kyle Fischer
Graduate student
858-453-4100 x1073
kfischer@salk.edu

Sarah Gilmour
Lab assistant
858-453-4100 x1073
sgilmour@salk.edu

Anupam Garg
Graduate student
858-453-4100 x1713
anupam@salk.edu

Tony Ito-Cole
Lab tech
858-453-4100 x1073
tito-cole@salk.edu

Matt Jacobs
Research assistant
858-453-4100 x1073
mjacobs@salk.edu

Ashley Juavinett
Graduate student
858-453-4100 x1064
ajuavinett@ucsd.edu

Megan Kirchgessner
Graduate student
858-453-4100 x1073
mkirchgessner@salk.edu

Su-Yee Lee
Lab tech
858-453-4100 x1073
sulee@salk.edu

Michael Lingelbach
Lab tech
858-453-4100 x1073
mlingelbach@salk.edu

Ethan McBride
Graduate student
858-453-4100 x1073
emcbride@salk.edu

Mohammad Rashid
Lab tech
858-453-4100 x1073
mrashid@salk.edu

Euiseok Kim
Postdoctoral fellow
858-453-4100 x1073
eukim@salk.edu

Espoir Kyubwa
Graduate student
858-453-4100 x1064
ekyubwa@ucsd.edu

Peichao Li
Research associate
858-453-4100 x1073
peli@salk.edu

Esther Richler
Postdoctoral fellow
858-453-4100 x1073
erichler@salk.edu

Alumni

Dennis L. Barbour
Assistant professor
Washington University in St-Louis
dbarbour@biomed.wustl.edu

Victor Borrell Franco
Principal investigator
Universidat Miguel Hernandez
Instituto de Neurociencias de Alicante
vborrell@umh.es

Farran Briggs
Assistant professor
Geisel School of Medicine at Darmouth
farran.briggs@darmouth.edu

Soumya Chatterjee
Postdoctoral fellow
Harvard Medical School
soumya_chatterjee@hms.harvard.edu

Jiwon Choi
Postdoctoral fellow
choi@salk.edu

Ali Haydar Cetin
Postdoctoral fellow
acetin@salk.edu

Marina Garrett
Graduate student
University of California San Diego
megarret@salk.edu

Ian Nauhaus
Postdoctoral fellow
inauhaus@salk.edu

Fumitaka Osakada
Postdoctoral fellow
fosakada@salk.edu

Noriko Osakada
Research assistant
nosakada@salk.edu

Mauricio De La Parra
Research assistant
University of California San Francisco
mdelaparra@ohns.ucsf.edu

Cristina Garcia Frigola
PhD investigator
Universidat Miguel Hernandez
Instituto de Neurociencias de Alicante
c.garcia@umh.es

Andrea Hasenstaub
Assistant professor
University of California San Francisco
ahasenstaub@ohns.ucsf.edu

Delaine Larsen
Postdoctoral fellow
University of California Davis
ddlarsen@ucdavis.edu

David Lyon
Assistant professor
University of California Irvine
Department of Anatomy and Neurobiology
dclyon@uci.edu

Tara Martinez
Graduate student
John Hopkins University
tmartine@jhsph.edu

James Marshel
Postdoctoral fellow
Stanford University
jmarshel@stanford.edu

Takuma Mori
Assistant professor
National Institute for Physiological Sciences
tmori@nips.ac.jp

Hoang Nhan
Postdoctoral fellow
University of California San Diego
hnhan@ucsd.edu

Jonathan Nassi
Postdoctoral fellow
Salk Institute for Biological Studies
jonathan_nassi@hms.harvard.edu

Jason Nathanson
Postdoctoral fellow
University of California San Diego
nathanson@ucsd.edu

Melissa Newton
Graduate student
University of California Berkeley
mlnewton8@gmail.com

Hendrikje Nienborg
Group leader
Universitaet Tuebingen
Center for Integrative Neuroscience
hendrikje.nienborg@cin.uni-tuebingen.de

Kristina Nielsen
Assistant professor
John Hopkins University
nielsen@mail.mb.jhu.edu

Cristina Nigro
Associate consultant at IMS Consulting Group
nigro.cristina@gmail.com

Stephani Otte
Postdoctoral fellow
University of California Berkeley
stephani.l.otte@gmail.com

Keith Roby
Medical student
University of California San Diego
kroby@ucsd.edu

Sandra Tye

stye11@wildblue.net

Beatriz Virgen
Nursing student
University of California Irvine

Karine von Bochmann
Research assistant and lab manager
kvb@salk.edu

Nicholas Wall
Postdoctoral fellow
wall@salk.edu

Ian Wickersham
Postdoctoral fellow
Massachussetts Institute of Technology
wickersham@mit.edu

Xiangmin Xu
Assistant professor
University of California Irvine
Department of Anatomy and Neurobiology
xiangmin.xu@uci.edu

Yoshiaki Yamaguchi
Assistant professor
University of Kyoto
Department of System Biology
yoshiy@pharm.kyoto-u.ac.jp

Amir Zarrinpar
Resident physician
University of California San Diego
azarrinp@ucsd.edu

Publications

Recent publications

Original Research Manuscripts

Nauhaus, I.*, Nielsen, K.J.*, Disney, A.A., Callaway, E.M. (In press) Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex. Nature Neuroscience.

Li Y., Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. (2012) Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proceedings of the National Academy of Sciences 109(11):4290-4295.

Marshel, J.H., Garrett, M.E., Nauhaus, I., Callaway, E.M. (2011) Functional specialization of seven mouse visual cortical areas. Neuron 72(6):1040-1054.

Nauhaus, I., Nielsen, K.J., Callaway, E.M. (2012) Nonlinearity of two-photon Ca2+ imaging yields distorted measurements of tuning for V1 neuronal populations. Journal of Neurophysiology 107(3):923-936.

Nielsen, K.J., Callaway, E.M., Krauzlis, R.J. (2012) Viral vector-based reversible neuronal inactivation and behavioral manipulation in the macaque monkey. Frontiers in Systems Neuroscience 6(48).

Vivar, C., Potter, M.C., Choi, J., Lee, J.Y., Stringer, T.P., Callaway, E.M., Gage, F.H., Suh, H., van Praag, H. (2012) Monosynaptic inputs to new neurons in the dentate gyrus. Nature Communications 3(1107).

Callaway, E.M., Borrel, V. (2011) Developmental sculpting of dendritic morphology of layer 4 neurons in visual cortex: influence of retinal input. Journal of Neuroscience 31(20): 7456-7470.

Choi, J., Callaway, E.M. (2011) Monosynaptic inputs to ErbB4 expressing neurons in mouse primary somatosensory cortex. Journal of Comparative Neurology 519(17):3402-3414.

Miyamichi, K., Amat, F., Moussavi F., Wang, C. Wickersham, I., Wall, N.R., Taniguchi, H., Tasic, B., Huang, Z.J., He, Z., Callaway, E.M., Horowitz, M.A., Luo, L. (2011) Cortical representations of olfactory input by trans-synaptic tracing. Nature 472(7342):191-196.

Osakada, F., Mori, T., Cetin, A.H., Marshel, J.H., Virgen, B., Callaway, E.M. (2011) New rabies variants for monitoring and manipulating activity and gene expression in defined neural circuits. Neuron 71(4): 617-631.

Reviews

Callaway, E.M., Marder, E. (2012) Common features of diverse circuits. Current Opinion in Neurobiology 22(4):565-567.

Selected publications

Original Research Manuscripts

Lyon, D.C., Nassi, J.J. & Callaway, E.M. (2010) A disynaptic relay from superior colliculus to dorsal stream visual cortex in macaque monkey. Neuron 65(2), 270-279.

Marshel, J.H., Mori, T., Nielsen, K.J. & Callaway, E.M. (2010) Targeting single neuron networks for gene expression and cell labeling in vivo. Neuron 67(4), 562-574.

Wall, N.R., Wickersham, I.R., Cetin, A., De La Parra, M., Callaway, E.M. (2010) Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus. Proceedings of the National Academy of Sciences 107(50):21848-21853.

Xu, X. & Callaway, E.M. (2009) Laminar specificity of functional input to distinct types of inhibitory cortical neurons. Journal of Neuroscience 29, 70-85.

Wickersham, I., Lyon, D.C., Barnard, R.J.O., Mori, T., Finke, S., Conzelmann, K.-K., Young, J.A.T. & Callaway, E.M. (2007) Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons. Neuron 53, 639-647.

Tan, E.M., Yamaguchi, Y., Horwitz, G.D., Gosgnach, S., Lein, E.S., Goulding, M., Albright, T.D. & Callaway, E.M. (2006) Selective and quickly reversible inactivation of mammalian neurons in vivo using the drosophila allatostatin receptor. Neuron 51, 157-170.
Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. (2005) Excitatory cortical neurons form fine-scale functional networks. Nature 433, 868-873.

Chatterjee, S. & Callaway, E.M. (2003) Parallel color-opponent pathways to primary visual cortex. Nature 426, 668-671.

Yabuta, N.H., Sawatari, A. & Callaway, E.M. (2001) Two functional channels from primary visual cortex to dorsal visual cortical areas. Science 292, 297-300.

Dantzker, J.L. & Callaway, E.M. (2000) Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons. Nature Neuroscience 7, 701-707.

Sawatari, A. & Callaway, E.M. (1996) Convergence of magno- and parvocellular pathways in layer 4B of macaque primary visual cortex. Nature 380, 442-446.

Reviews

Hasenstaub, A.R. & Callaway, E.M. (2010) Paint it black (or red, or green): optical and genetic tools illuminate inhibitory contributions to cortical circuit function. Neuron 67(5), 681-684.

Callaway E.M. (2009) Transneuronal circuit tracing with neurotropic viruses. Current Opinion in Neurobiology 18, 617-623.

Nassi J.J. & Callaway, E.M. (2009) Parallel processing strategies of the primate visual system. Nature Reviews Neuroscience 10, 360-372.

Luo, L., Callaway, E.M. & Svoboda, K. (2008) Genetic dissection of neural circuits. Neuron 57, 634-660.

Complete publications

Original Research Manuscripts

Nauhaus, I.*, Nielsen, K.J.*, Disney, A.A., Callaway, E.M. (In press) Orthogonal micro-organization of orientation and spatial frequency in primate primary visual cortex. Nature Neuroscience.

Li Y., Aimone, J.B., Xu, X., Callaway, E.M., Gage, F.H. (2012) Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network. Proceedings of the National Academy of Sciences 109(11):4290-4295.

Marshel, J.H., Garrett, M.E., Nauhaus, I., Callaway, E.M. (2011) Functional specialization of seven mouse visual cortical areas. Neuron 72(6):1040-1054.

Nauhaus, I., Nielsen, K.J., Callaway, E.M. (2012) Nonlinearity of two-photon Ca2+ imaging yields distorted measurements of tuning for V1 neuronal populations. Journal of Neurophysiology 107(3):923-936.

Nielsen, K.J., Callaway, E.M., Krauzlis, R.J. (2012) Viral vector-based reversible neuronal inactivation and behavioral manipulation in the macaque monkey. Frontiers in Systems Neuroscience 6(48).

Vivar, C., Potter, M.C., Choi, J., Lee, J.Y., Stringer, T.P., Callaway, E.M., Gage, F.H., Suh, H., van Praag, H. (2012) Monosynaptic inputs to new neurons in the dentate gyrus. Nature Communications 3(1107).

Callaway, E.M., Borrel, V. (2011) Developmental sculpting of dendritic morphology of layer 4 neurons in visual cortex: influence of retinal input. Journal of Neuroscience 31(20): 7456-7470.

Choi, J., Callaway, E.M. (2011) Monosynaptic inputs to ErbB4 expressing neurons in mouse primary somatosensory cortex. Journal of Comparative Neurology. 519(17):3402-3414.

Miyamichi, K., Amat, F., Moussavi F., Wang, C. Wickersham, I., Wall, N.R., Taniguchi, H., Tasic, B., Huang, Z.J., He, Z., Callaway, E.M., Horowitz, M.A., Luo, L. (2011) Cortical representations of olfactory input by trans-synaptic tracing. Nature, 472(7342):191-196.

Osakada, F., Mori, T., Cetin, A.H., Marshel, J.H., Virgen, B., Callaway, E.M. (2011) New rabies variants for monitoring and manipulating activity and gene expression in defined neural circuits. Neuron 71(4): 617-631.

Choi, J., Young, J.A. & Callaway, E.M. (2010) Selective viral vector transduction of ErbB4 expressing cortical interneurons in vivo with a viral receptor-ligand bridge protein. Proceedings of the National Academy of Sciences 107(38), 1703-1078.

Hasenstaub, A.R., Otte, S., Callaway, E.M. & Sejnowski, T.J. (2010) Metabolic cost as a unifying principle governing neuronal biophysics. Proceedings of the National Academy of Sciences 107(27), 12329-12334.

Haubensak, W., Kunwar, P.S., Cai, H., Ciocchi, S., Wall, N.R., Ponnusamy, R., Biag, J., Dong, H.W., Deisseroth, K., Callaway, E.M., Fanselow, M.S., Lüthi, A., Anderson, D.J. (2010) Genetic dissection of an amygdalia microcircuit that gates condioned fear. Nature 468(7321):270-276.

Heider, B., Nathanson, J.L., Isacoff, E.Y., Callaway, E.M., Siegel, R.M. (2010) Two-photon imaging of calcium in virally transfected striate cortical neurons of behaving monkeys. PLoS One 5(11):e13829.

Lyon, D.C., Nassi, J.J. & Callaway, E.M. (2010) A disynaptic relay from superior colliculus to dorsal stream visual cortex in macaque monkey. Neuron 65(2), 270-279.

Marshel, J.H., Mori, T., Nielsen, K.J. & Callaway, E.M. (2010) Targeting single neuron networks for gene expression and cell labeling in vivo. Neuron 67(4), 562-574.

Otte, S., Hasenstaub, A. & Callaway, E.M. (2010) Cell type-specific control of neuronal responsiveness by gamma-band oscillatory inhibition. Journal of Neuroscience 30(6), 2150-2159.

Wall, N.R., Wickersham, I.R., Cetin, A., De La Parra, M., Callaway, E.M. (2010) Monosynaptic circuit tracing in vivo through Cre-dependent targeting and complementation of modified rabies virus. Proceedings of the National Academy of Sciences 107(50):21848-21853.

Weible, A.P., Schwarcz, L., Wickersham, I.R., Deblander, L., Wu, H., Callaway, E.M., Seung, H.S., Kentros, C.G. (2010) Transgenic targeting of recombinant rabies virus reveals monosynaptic connectivity of specific neurons. Journal of Neuroscience 30(49), 16509-16513.

Xu, X., Roby, K., & Callaway, E.M. (2010) Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells. Journal of Comparative Neurology 518(3), 389-404.

Nathanson, J.L., Jappelli, R., Scheeff, E.D., Manning, G., Obata, K., Brenner, S., Callaway, E.M. (2009) Short promoters in viral vectors drive selective expression in mammalian inhibitory neurons, but do not restrict activity to specific inhibitory cell-types. Frontiers in Neural Circuits 3, 19.

Nathanson, J.L., Yanagawa, Y., Obata, K., & Callaway, E.M. (2009) Preferential labeling of inhibitory and excitatory cortical neurons by endogenous tropism of adeno-associated virus and lentiviral vectors. Neuroscience 161, 441-450.

Wehr, M., Hostick, U., Kyweriga, M. (2009) Transgenic silencing of neurons in the mammalian brain by expression of the allatostatin receptor (AlstR). Journal of Neurophysiology 102(6), 3781.

Xu, X. & Callaway, E.M. (2009) Laminar specificity of functional input to distinct types of inhibitory cortical neurons. Journal of Neuroscience 29(1), 70-85.

Barbour, D.L. & Callaway, E.M. (2008) Excitatory local connections of superficial neurons in rat auditory cortex. Journal of Neuroscience 28(44), 11174-11185.

Larsen, D.D., Wickersham, I.R. & Callaway, E.M. (2008) Retrograde tracing with recombinant rabies virus reveals correlations between projection targets and dendritic architecture in layer 5 of mouse barrel cortex. Frontiers in Neural Circuits 1(5).

Tan, W., Janczewski, W.A., Yang, P., Shao, X.M., Callaway, E.M. & Feldman, J.L. (2008) Rapid silencing of preBötzinger complex somatostatin-expressing neurons induces persistent apnea in adult awake rats. Nature Neuroscience 11(5): 538-540.

Nassi, J.J. & Callaway, E.M. (2007) Specialized circuits from primary visual cortex to V2 and area MT. Neuron 55(5), 799–808.

Wickersham, I., Finke, S., Conzelmann, K.-K., & Callaway, E.M. (2007) Retrograde neuronal tracing with a deletion-mutant rabies virus. Nature Methods 4(1), 47-49.

Wickersham, I., Lyon, D.C., Barnard, R.J.O., Mori, T., Finke, S., Conzelmann, K.-K., Young, J.A.T. & Callaway, E.M. (2007) Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons. Neuron 53(5), 639-647.

Borrel, V., Kaspar, B.K., Gage, F.H. & Callaway, E.M. (2006) In vivo evidence for radial migration of neurons by long-distance somal translocation in the developing ferret visual cortex. Cerebral Cortex 16(11), 1571-1583.

Gosgnach, S., Lanuza, G.M., Butt, S.J.B., Saueressig, H., Zhang, Y., Velasquez, T., Reithmacher, D., Callaway, E.M., Kiehn, O. and M. Goulding (2006) V1 spinal neurons regulate the speed of vertebrate locomotor outputs. Nature 440(7081), 215-219.

Nassi, J.J & Callaway, E.M. (2006) Multiple circuits relaying primate parallel visual pathways to the middle temporal area. Journal of Neuroscience 26(49), 12789-12798.

Nassi, J.J.*, Lyon, D.C.* & Callaway, E.M. (2006) The parvocellular LGN provides a robust disynaptic input to the visual motion area MT. Neuron 50(2), 319-327. *Co-first authors.

Larsen, D.D. & Callaway, E.M. (2006) Development of layer-specific axonal arborizations in mouse primary somatosensory cortex. Journal of Comparative Neurology 494(3), 398-414.

Sceniak, M.P, Chatterjee, S., & Callaway, E.M. (2006) Visual spatial summation in macaque geniculocortical afferents. Journal of Neurophysiology 96(6), 3474-3484.

Tan, E.M., Yamaguchi, Y., Horwitz, G.D., Gosgnach, S., Lein, E.S., Goulding, M., Albright, T.D. & Callaway, E.M. (2006) Selective and quickly reversible inactivation of mammalian neurons in vivo using the drosophila allatostatin receptor. Neuron 51(2), 157-170.

Xu, X., Roby, K., & Callaway, E.M. (2006) Mouse cortical inhibitory neuron type that co-expresses somatostatin and calretinin. Journal of Comparative Neurology 499(1), 144-160.

Zarrinpar, A. & Callaway, E.M. (2006) Local connections to specific types of layer 6 neurons in the rat visual cortex. Journal of Neurophysiology 95(3), 1751-1761.

Borrell, V., Yoshimura, Y. & Callaway, E.M. (2005) Targeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation. Journal of Neuroscience Methods 143, 151-158.

Briggs, F. & Callaway, E.M. (2005) Laminar patterns of local excitatory input to layer 5 neurons in macaque primary visual cortex. Cerebral Cortex 15(5), 479-488.

Lein, E.S., Callaway, E.M., Albright, T. D. & Gage, F.H. (2005) Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3-dimensional reconstruction. Journal of Comparative Neurology 485, 1-10.

Yoshimura, Y. & Callaway, E.M. (2005) Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity. Nature Neuroscience 8(11), 1552-1559.

Yoshimura, Y., Dantzker, J.L. & Callaway, E.M. (2005) Excitatory cortical neurons form fine-scale functional networks. Nature 433, 868-873.

Brivanlou, I.H., Dantzker, J.L.M., Stevens, C.F. & Callaway, E.M. (2004) Topographic specificity of functional connections from hippocampal CA3 to CA1. Proceedings of the National Academy of Sciences U.S.A. 101, 2560-2565.

Chatterjee, S. & Callaway, E.M. (2003) Parallel color-opponent pathways to primary visual cortex. Nature 426, 668-671.

Borrell, V. & Callaway, E.M. (2002) Reorganization of exuberant axonal arbors contributes to the development of laminar specificity in ferret visual cortex. Journal of Neuroscience. 22, 6682-6695.

Chatterjee, S. & Callaway, E.M. (2002) S cone contributions to the magnocellular visual pathway in macaque monkey. Neuron 35, 1135-1146.

Lechner, H.A.E., Lein, E.S. & Callaway, E.M. (2002) A genetic method for selective and quickly reversible silencing of mammalian neurons. Journal of Neuroscience. 22, 5287-5290.

Briggs, F. & Callaway, E.M. (2001) Layer-specific input to distinct cell types in layer 6 of monkey primary visual cortex. Journal of Neuroscience 21, 3600-3608.

Butler, A.K., Dantzker, J.L., Shah, R.B. & Callaway, E.M. (2001) Development of visual cortical axons: Layer-specific effects of extrinsic influences and activity blockade. Journal of Comparative Neurology. 430, 321-331.

Yabuta, N.H., Sawatari, A. & Callaway, E.M. (2001) Two functional channels from primary visual cortex to dorsal visual cortical areas. Science 292, 297-300.

Dantzker, J.L. & Callaway, E.M. (2000) Laminar sources of synaptic input to cortical inhibitory interneurons and pyramidal neurons. Nature Neuroscience 7, 701-707.

Sawatari, A. & Callaway, E.M. (2000) Diversity and cell type specificity of local excitatory connections to neurons in layer 3B of monkey primary visual cortex. Neuron 25, 459–471.

Yabuta, N.H., Butler, A.K. & Callaway, E.M. (2000) Laminar specificity of local circuits in barrel cortex of ephrin-A5 knockout mice. Journal of Neuroscience 20, RC88, 1-4.

Furuta, T., Wang, S.S., Dantzker, J.L., Dore, T.M., Bybee, W.J., Callaway, E.M., Denk, W. & Tsien, R.Y. (1999) Brominated 7-hydroxycoumarin-4-ylmethyls: photolabile protecting groups with biologically useful cross-sections for two photon photolysis. Proceedings of the National Academy of Sciences U.S.A. 96, 1193-1200.

Callaway, E.M. (1998) Prenatal development of layer-specific local circuits in primary visual cortex of the macaque monkey. Journal of Neuroscience 18, 1505-1527.

Dantzker, J.D. & Callaway, E.M. (1998) The development of local, layer-specific visual cortical axons in the absence of extrinsic influences and intrinsic activity. Journal of Neuroscience 18, 4145-4154.

Yabuta, N.H. & Callaway, E.M. (1998) Functional streams and local connections of layer 4C neurons in primary visual cortex of the macaque monkey. Journal of Neuroscience 18, 9489-9499.

Yabuta, N.H. & Callaway, E.M. (1998) Cytochrome oxidase blobs and intrinsic horizontal connections of layer 2/3 pyramidal neurons in primate V1. Visual Neuroscience 15, 1007-1027.

Callaway, E.M. & Lieber, J.L. (1996) Development of axonal arbors of layer 6 pyramidal neurons in ferret primary visual cortex. Journal of Comparative Neurology 376, 295-305.

Callaway, E.M. & Wiser, A.K. (1996) Contributions of individual layer 2-5 spiny neurons to local circuits in macaque primary visual cortex. Visual Neuroscience 13, 907-922.

Sawatari, A. & Callaway, E.M. (1996) Convergence of magno- and parvocellular pathways in layer 4B of macaque primary visual cortex. Nature 380, 442-446.

Wiser, A.K. & Callaway, E.M. (1996) Contributions of individual layer 6 pyramidal neurons to local circuitry in macaque primary visual cortex. Journal of Neuroscience 16, 2724-2739.

Callaway, E. M. & Katz, L. C. (1993) Photostimulation using caged glutamate reveals functional circuitry in living brain slices. Proceedings of the National Academy of Sciences U.S.A. 90, 7661-7665.

Callaway, E. M. & Katz, L. C. (1992) Development of axonal arbors of layer 4 spiny neurons in cat striate cortex. Journal of Neuroscience 12, 570-582.

Callaway, E. M. & Katz, L. C. (1991) Effects of binocular deprivation on the development of clustered horizontal connections in cat striate cortex. Proceedings of the National Academy of Sciences U.S.A. 88, 745-749.

Callaway, E. M. & Katz, L. C. (1990) Emergence and refinement of clustered horizontal connections in cat striate cortex. Journal of Neuroscience 10, 1134-1153.

Callaway, E. M., Soha, J. M. & Van Essen, D. C. (1989) Differential loss of neuromuscular connections according to activity level and spinal position of neonatal rabbit soleus motor neurons. Journal of Neuroscience 9, 1806-1824.

Callaway, E. M. & Van Essen, D. C. (1989) Slowing of synapse elimination by alpha-bungarotoxin superfusion of the neonatal rabbit soleus muscle. Developmental Biology 131, 356-365.

Soha, J. M., Callaway, E. M. & Van Essen, D. C. (1989) Lack of fiber type selectivity during reinnervation of neonatal rabbit soleus muscle. Developmental Biology 131, 401-414.

Callaway, E. M., Soha, J. M. & Van Essen, D. C. (1987) Competition favoring inactive over active motor neurons during synapse elimination. Nature 328, 422-426.

Reviews, Commentaries and Book Chapters

Callaway, E.M., Marder, E. (2012) Common features of diverse circuits. Current Opinion in Neurobiology 22(4):565-567.

Hasenstaub, A.R. & Callaway, E.M. (2010) Paint it black (or red, or green): optical and genetic tools illuminate inhibitory contributions to cortical circuit function. Neuron 67(5), 681-684.

Callaway, E.M. (2009) Parallel processing strategies of the primate visual system. Nature Reviews Neuroscience 10, 360-372.

Callaway E.M. (2009) Transneuronal circuit tracing with neurotropic viruses. Current Opinion in Neurobiology 18, 617-623.

Luo, L., Callaway, E.M. & Svoboda, K. (2008) Genetic dissection of neural circuits. Neuron 57(5), 634-660.

Nielsen, K.J. & Callaway, E.M. (2008) More than a feeling: Sensation from cortical stimulation. Nature Neuroscience 11(1), 10-11.

Callaway, E.M. (2006) Should I stay or should I go? Presynaptic boutons in the adult cortex still haven’t made up their minds. Neuron 49(6), 780-783.

Callaway, E.M. & Sanes, J.R. (2006) Editorial overview. New technologies. Current Opinions in Neurobiology 16(5), 540-542.

Callaway, E.M. (2005) A molecular and genetic arsenal for systems neuroscience. Trends in Neuroscience 28(4), 196-201.

Callaway, E.M. (2005) Neural substrates within primary visual cortex for interactions between parallel visual pathways. Progress in Brain Research 149, 59-64.

Callaway, E.M. (2005) Structure and function of parallel pathways in the primate early visual system. Journal of Physiology 566(1), 13-19.
Callaway, E.M. (2004) Close encounters: How cortical neurons find and connect to their correct synaptic partners depends on the cell type. Neuron 43, 156-158.

Callaway, E.M. (2004) Feedforward, feedback and inhibitory connections in primate visual cortex. Neural Networks 17, 625-632.

Horwitz, G.D. & Callaway, E.M. (2004) Antisense inhibition of reward learning. Nature Neuroscience 7, 1023-1024.

Siegel, R.M. & Callaway, E.M. (2004) Francis Crick’s legacy for neuroscience: Between the and the . PLoS Biology 2, 2029-2032.

Callaway, E.M. (2003) Cell types and local circuits in primary visual cortex of the macaque monkey. In The Visual Neurosciences, Chalupa, L. and Werner, J. Eds., MIT Press (Cambridge).

Callaway, E.M. (2002) Cell type specificity of local cortical connections. Journal of Neurocytology 31, 231-237.

Callaway, E.M. (2002) Orientation tuning – A crooked path to the straight and narrow. Neuron 36, 783-785.

Callaway, E.M. and Yuste, R. (2002) Stimulating neurons with light. Current Opinions in Neurobiology, 12, 587-592.

Callaway, E.M. (2001) Neural mechanisms for the generation of visual complex cells. Neuron 32, 378-380.

Callaway, E.M. (1998) Local circuits in primary visual cortex of the macaque monkey. Annual Review of Neuroscience 21, 47-74.

Callaway, E.M. (1998) Visual scenes and cortical neurons: What you see is what you get. Proceedings of the National Academy of Sciences U.S.A. 95, 3344-3345.

Callaway, E.M. (1994) Shedding light on neural circuits. Current Biology 4, 1010-1012.

Katz, L. C. & Callaway, E.M. (1992) Development of local circuits in mammalian visual cortex. Annual Review of Neuroscience 15, 31-56.

Katz, L. C. & Callaway, E.M. (1991) Emergence and refinement of local circuits in cat striate cortex. In Development of the visual system, Shatz, C.J. and D. M-K Lam, eds., MIT Press (Cambridge).

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Contact Us

Mail
Systems Neurobiology Laboratories – Callaway Lab
10010 North Torrey Pines Road
La Jolla, CA 92037

Phone
858-453-4100, x1073, x1326 and x1064

Fax
858-546-8526